One or two members of the club present a summary of the chosen paper that the whole group has read. The recent joint consensus statement from the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) favors dipeptidyl peptidase-4 (DPP-4) inhibitors over sulfonylureas as second- or third-line therapy in type 2 diabetes management. Update 06-11-2019 | CAROLINA shows neutral cardiovascular profile for modern sulfonylurea. Then, the discussion begins. Presenters: Julio Rosenstock, MD; Mark Espeland, PhD; Steven E. Kahn, MB, ChB; Nikolaus Marx, MD, FESC, FAHA; Bernard Zinman, CM, MD; Darren K. McGuire, MD, MHSc; Matthew C. Riddle, MD. The original goal of the journal club in Osler’s day was to share expensive texts and to review literature as a group. Over time, the goals of journal clubs have evolved to include discussion and review of current literature and development of skills for evaluating medical literature. CARMELINA ® is a multi-national, randomised, double-blind, placebo-controlled clinical trial that involved 6,979 adults with type 2 diabetes from 27 countries at more than 600 sites observed for a median duration of 2.2 years. Supplement to: Neal B, Perkovic V, Mahaffey KW, et al. Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. The second key secondary endpoint was a composite endpoint of treatment sustainability, defined as the percentage of patients taking trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, without >2% weight gain, and without moderate/severe hypoglycaemic episodes during maintenance phase. A journal club is a regular gathering of scientists to discuss a scientific paper found in a research journal. Monday 10 June: 16:30–18:30.

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